Show HN: Web Potions – let ChatGPT or Claude restyle the web you browse
Article URL: https://github.com/leofritsch/web-potions Comments URL: https://news.ycombinator.com/item?id=50404138 Points: 1 # Comments: 1
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OpenAI / ChatGPT
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Measuring how AI agents handle everyday wet-lab science
OpenAI introduces BioBasicsBench, a 100-task benchmark measuring how well AI agents interpret raw experimental data and handle everyday wet-lab science.
Show HN: Cerea – yet another self-hosted LLM chat front end
Here is Cerea, a self-hostable, open-source (Apache 2.0) chat+agent frontend for LLMs. It works alone with any OpenAI-compatible inference provider, but it's way better when coupled with the model gateway I'm also developing, Pystino (https://github.com/paoloviviani/Pystino).I came to this after struggling to find a hosted chat interface that was truly open source, that I really enjoyed to use, and that was simple enough to be shared and used by family. In particular, I was looking for something that could provide the smooth and integrated user experience of commercial products for the tasks needed by family (e.g., document editing, form filling, notes and knowledge management), but backed by open models hosted wherever I decide.Then it became richer, now supporting: remote coding agents (wrapping Opencode), delegation and coordination between agents, integration between chat/projects and code agents (this one to me is a pain point for Claude, which I use at work), projects, RAG, rich artifacts support, schedules, and more.You can try it yourself, either cloning the full repo and head to Cerea/kit, or just the deploy kit with a script (https://github.com/paoloviviani/Cerea#quick-start).It's just a docker compose with a ./configure script that helps to generate a sensible .env for the specific scenario. It works in the browser and as a PWA on mobile.I hope you'll enjoy, feel free to reach out for questions. Comments URL: https://news.ycombinator.com/item?id=50384502 Points: 1 # Comments: 0
Show HN: LLMBrake – Per-customer dollar caps for OpenAI/Anthropic API calls
Article URL: https://github.com/llmbrake/llmbrake Comments URL: https://news.ycombinator.com/item?id=50386174 Points: 2 # Comments: 0
Show HN: Umbel – Remote-control agent CLIs over tmux
Been using this in all my sessions the last months. Opus 5.5 (over MCP) spawns Deepseek flash agents - and codex for audits etc. Very curious to hear what the HN crowd thinks/makes of it. Comments URL: https://news.ycombinator.com/item?id=50383189 Points: 1 # Comments: 0
Flipsnack grows product signups with conversion optimization
Flipsnack focused its ChatGPT Ads campaigns on getting people to try its product, growing registrations while lowering the cost per signup.
Merge builds product and business tools with OpenAI technology
Merge uses GPT-6 Astra, ChatGPT, and Codex to review product code and support marketing. Its teams also use AI to plan executive dinners and prepare sales updates.
Setting a new standard for responsible AI infrastructure
OpenAI introduces its National Community Compact and Compute Campus Policy Blueprint to protect local resources, create jobs, and guide responsible AI infrastructure development.
Show HN: Lmux – A Lightweight macOS Terminal for Claude Code and Codex
Article URL: https://github.com/sooftware/lmux Comments URL: https://news.ycombinator.com/item?id=50378582 Points: 2 # Comments: 0
A thousand fewer paths to root
OpenAI built an autonomous pipeline that found, validated, and generated patches for 948 local privilege-escalation vulnerabilities in the Linux kernel.
El Agente F\'armaco: A Scalable AI Scientist for Drug Discovery
arXiv:2611.03832v1 Announce Type: new Abstract: Computational drug discovery offers a growing range of tools for proposing and evaluating molecules, but combining them and deciding what to do next still requires substantial expert effort. Here, we introduce El Agente F\'armaco, an AI scientist that uses modern large language model (LLM) technology to turn discovery goals expressed in everyday language into complex, scalable computational screening workflows. The agentic harness selects scientific tools, reviews their results, and adjusts subsequent steps to the target and the user's objectives. Our approach centers on a shared scientific memory: F\'armaco Atlas, which stores molecules, structures, and results together with their provenance -- a record of how they were obtained. The agent uses targeted database queries to retrieve the evidence needed for each decision. A single request can launch calculations for an entire collection of molecules, without requiring a separate LLM decision for every compound. This design limits the information the model must process as screening collections grow, while keeping the underlying results available for inspection and further analysis. The integrated tools support molecule generation, prediction of binding and molecular properties, and searches for compounds available for purchase. In a retrospective comparison with an expert-led campaign, the agent proposed chemically distinct candidates with competitive docking scores and higher calculated drug-likeness under explicitly imposed selection criteria. In a 22-task benchmark against plain tool calls and Codex, the agent achieved the highest observed mean model-judged score, with lower median cumulative token use and peak context. F\'armaco provides a foundation for flexible, scalable drug discovery workflows that connect scientific reasoning with an enduring, traceable record of computational work.
Introducing Images 2.6
Images 2.6 brings faster image generation, GIF creation, more precise editing, and new API controls across ChatGPT, Codex, and the API.
v0.44.0
ComfyUI v0.44.0 introduces multiple new partner nodes for tools like Patina, VEED, BFL, Ideogram, Pruna, MiniMax, Topaz, Sonilo, and OpenAI, adding features such as higher resolution video upscaling, context window editing, and new models. Enhancements include support for ProRes and custom chroma subsampling in video saving, improved frontend handling with pinned versions, optimized tensor comparisons, and better VAE compute dtype control. Performance optimizations address redundant concatenations and memory management, while bug fixes resolve crashes related to VAE decoding and prefetch queue cleanup. The release also updates workflow templates, embedded documentation, and default settings, with contributions from new developers.
The biggest names in AI are backing a new way to opt out of scraping
OpenAI, Google, Microsoft, and Anthropic say they will adopt a new standard that publishers can use to opt out of being scraped by AI, as reported earlier by Search Engine Roundtable. With this control, publishers can apply their AI training preferences across multiple AI companies, instead of setting them individually. The shared "policy token" signal […]
GitHub Copilot Fusion Launches with Dual Capabilities: Intelligent Model Orchestration and Local Model Routing
On October 28, 2026, GitHub released the official version of Copilot Fusion, simultaneously introducing an experimental local model routing feature. This capability enables automatic invocation of local models such as MAI Code 1.1 Flash on Windows devices and activates intelligent routing within VS Code, the CLI, and the Copilot App. The system automatically selects and combines cloud models—like those from OpenAI, Anthropic, and Google—based on three effort levels: Standard, High, and Max, achieving performance close to Claude Code while cutting costs in half during coding evaluations.
ChatGPT credit officially doubled, but free resets may soon be a thing of the past
After being criticized by users for a month, OpenAI has finally decided to stop tinkering with everyone’s usage limits. Just now, OpenAI’s head of product, Tibo, suddenly announced that he would significantly increase the usage limits for the ChatGPT Pro series and Business....
API credits benefit for eligible ChatGPT subscriptions
API credits benefit for eligible ChatGPT subscriptions. Earlier this month Anthropic announced a generous new benefit for their Max and Team subscriptions: $100, $200, and $500 per month subscribers would get the equivalent quantity of (expiring) credits to use with the Anthropic API.
GitHub releases Copilot Fusion, an automated multi-model orchestration tool that boosts coding efficiency and cost-effectiveness.
At Universe 2026, GitHub unveiled Copilot Fusion, an intelligent orchestration layer that automatically routes and combines models from OpenAI, Anthropic, Google, and others to complete coding tasks—eliminating the need for developers to manually select models. It integrates existing automatic model-selection technologies with Project HydraFusion, previewed in September. Once the model selector is enabled, the system automatically adopts execution modes such as single-model, cascading, or critique, based on task complexity.
Apple’s lawsuit against OpenAI over trade secret theft scheduled for summer 2027: a tug-of-war over confidential information involving former employees
Apple’s trade secret case against OpenAI is set to go before Judge Edward Davila at the U.S. District Court for the Northern District of California on July 19, 2027, at 9:00 a.m. A case management order was issued on October 28, mandating that both parties engage in document exchange, discovery, and filing motions over the coming months. Document submissions must be completed by February 5 next year; fact-finding will conclude on March 12; expert discovery wraps up on April 28; expert testimony will be heard on June 10; and a final pre-trial conference is scheduled for June 24.
b11953
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